HumanKine™ TGF beta 2

Recombinant human Transforming Growth Factor (TGF) beta 2 expressed in engineered human cells. TGF beta 2 is a 25 kDa disulfide linked homodimeric protein and belongs to the TGF beta superfamily. TGF beta 2 is important for immune homeostasis by balancing lymphocyte proliferation, apoptosis, hematopoiesis and embryogenesis. TGF beta 2 is crucial in cell growth, differentiation, and survival. TGF beta 2 is a strong growth inhibitor for normal and transformed epithelial, lymphoid, fibroblasts, and keratinocytes cells. TGF beta 2 is a tumor suppressor in the early stages of carcinogenesis, but in the later stages acts as a tumor promoter by inducing epithelial-mesenchymal transition and stimulating angiogenesis. TGF beta 2 inhibits NK cells growth as well as B and T cell proliferation.